李逸明 研究教授 生物医药

63374

李逸明

研究教授

生物医药创新中心

E-mail: liym3@sustc.edu.cn


研究方向

用于生产重组蛋白的分子生物学、细胞生物学和生物化学技术的研发;蛋白质纯化、药用蛋白质质量及稳定性分析;用于合成化学药物及中间体的生物酶催化剂的研究及开发;酶固定化技术。 

教育经历

1998.8. – 2002.4.    哈佛大学医学院,博士后

1997.12. – 1998.7.  瑞典乌普萨拉大学,博士后

1994.8. – 1997.11.  瑞典乌普萨拉大学生物化学系,博士

1990.1. – 1994.7.    乌瑞典普萨拉大学植物、卡洛林斯卡皇家医学研究院,博士后

1985.3. – 1988.8.    中山大学生物系,博士

1982.3. –1985.1.     中山大学生物系,硕士

1978.3. – 1982.1.    中山大学生物系,学士

工作经历

2018.10. – 至今       南方科技大学,研究教授

2016.10. – 2018.9.  美国Biosolutions-Plus,首席科学官

2009.9. – 2016.8.    美国MedImmune(阿斯利康),科学家II

2002.5. – 2009.9.    美国人类基因组公司,科学家、高级科学家

1988.9. – 1989.12.  深圳市科委 科技交流中心,工程师

代表性论文

1.Li YM, Polozova A, Gruia F, and Feng J. (2014) Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores. Analytical Chemistry, 86: 6850-6857.

2.Li YM, Stafford W, Hesselberg M, Hayes D, Wu Z. Byrne M. (2011) Characterization of the self-association of human interferon-α2b, albinterferon-α2b, and pegasys. Journal of Pharmaceutical Sciences. 101-1: 68–80

3.Irwin N, Li YM, O’toole JE and Benowitz, L. (2006) Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc. Natl. Acad. Sci. USA 103(48): 18320-18325.

4.Li YM, Irwin N, Yin YQ, Lanser M and Benowitz L. (2003) Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP. J. Neurosci. 23 (21): 7830-7838.

5.Liu CM, Li YM, Semenov M, Han C, Baeg GH, Tan Y, Zhang ZH, Lin XH and He X.  (2002) Control of -catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.

6.Gottschalk I, Li YM and Lundahl P. (2000) Chromatography on cells: Analysis of solute interactions with the glucose transporter Glut 1 in human red cells adsorbed on lectin-gel beads. J Chromat B  Biomed Sci Appl. 739 (1) 55-62. 

7.Li YM, Liao JL, Zhang R, Henriksson H and Hjerten S. (1999) Continuous beds for microchromatography: chromatogocusing and anion exchange chromatography. Anal Biochem. 267 (1): 121-124.

8.Li YM, Franklin G, Cui HM, Svensson K, He XB, Adam G, Ohlsson R and Pfeifer S. (1998) The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans. J Biol Chem 273: 28247-28252.

9.Hjerten S, Ericson C, Li YM and Zhang R. (1998) Capillary electrophoresis and capillary chromatography. Theoretical analogies and practical differences. Biomed Chromatogr.12: 120-121.

10.Liao JL, Li YM and Hjerten S. (1996) Continuous beds for microchromatography: reversed phase chromatography. Anal Biochem. 234: 27-30.

11.Li YM, Brostedt P, Hjerten S, Nyberg F and Silberring J. (1995) Capillary LC-FAB MS using a high-resolving cation-exchanger, based on a continuous chromatographic matrix. Application to studies on neuropeptide peptidases. J Chromatogr B. 664: 426-430.

12.Li YM, Liao JL, Nakazato K, Mohammad J, Terenius L and Hjerten S. (1994) Continuous bed for microchromatography: cation-exchange chromatography. Anal Biochem. 223: 153-158.

13.Silberring J, Li YM, Nyberg F. and Hjerten S. (1993) Strategies in studies on neuropeptide processing by mass spectrometry. Biochem Soc Trans. 22: 136-140.

14.Mohammad J, Li YM, El-Ahman M, Nakazato K, Pettersson G and Hjerten S. 1993. Chiral-recognition chromatography of b-blockers on continuous polymer beds with immobilized cellulase as enantioselective protein. Chirality 5: 464-470. 

15.Hjerten S, Li YM, Liao JL, Mohammad J, Nakazato K and Pettersson G. (1992) Continuous beds: high-resolving, cost-effective chromatographic matrices. Nature 356: 810-811.

16.Jiang JB and Li YM (1988) Sarcocystosis induced by Sarcocystis suihominis in China. In “Zoonoses in China” (Yu ES and Xu BK eds.) pp.888-891.

17.Li YM and Lian ZQ (1986) Studies on man-pig cyclic infection of Sarcocystis suihominis found in Yunnan Province, China. Acta Zoologica Sinica 32(4): 329-334.

专利

1. 中国专利(已提交):通过点突变在毕赤酵母中表达有活性的嗜热脂肪芽胞杆菌脂肪酶。

          申请人:王瑞工、刘伊佳、李逸明

2. 美国专利:Method of Purifying albumin-fusion proteins

          申请人:Pabst, Timothy; Fonsecaf, Mariko; Thompson, Christopher

                       Hunter, Alan;Wang, Xiangyang;Tie, Liu;LI, Yiming

          申请号:US2016/022003

          发表日期:2016年9月15日