张博 研究副教授 生物医学工程

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张博
研究副教授  
生物医学工程创新中心
E-mail: zhangb3@sustc.edu.cn


        南方科技大学创新创业学院副教授。张博于美国斯坦福大学化学系取得物理化学博士学位;于北京大学化学与分子工程学院取得化学学士学位 ; 于2006年取得全国化学奥林匹克竞赛金牌。张博博士于2017年入选福布斯中国 30位30岁以下精英榜 (医疗、健康和科技板块)。张博博士在新材料与生物技术研发领域有超过十年经验,发表了30篇原创性科研论文,均发表在国际高影响力学术期刊上(Nature Medicine, Nature Materials, Nature Photonics, Nature Communications, Chemical Science, PloS One, NanoResearch等)。其中,张博博士在自然医学杂志(杂志影响因子30.357)上以第一作者发表的一型糖尿病诊断技术获得全世界媒体关注,张博博士以第一作者及通讯作者撰写的寨卡病毒特异诊断技术也在2017年初发表在自然医学杂志上,并在业界产生很大影响。张博博士以首席科学家身份主持过美国卫生部国立卫生研究院(NIH)等著名学术机构的科研项目。张博博士持有两项国际专利,两项美国专利,以及一项中国专利。张博博士曾获得美国材料协会银奖,中国政府自费留学生奖学金,以及斯坦福大学William S. Johnson学者等重要奖项。


研究方向:

张博博士的研究方向是研发革命性的新材料和新型样品制备与检测技术,以根本上提高疾病诊断的灵敏度和特异性;为人类提供一种全球领先的健康管理和早期癌症筛查技术服务,比传统诊断和筛查技术更早期、更准确地发现癌症,从而使得早期、高效的外科和其他临床干预成为可能。这一方向可以应用于广阔的医疗大健康领域,包括无创产前诊断 NIPT、感染性疾病、药物研发等。我们的科研目标是引领人类核酸科技应用,提高人类大健康状况 。


发表期刊和会议论文

1. Bo Zhang (1st and Corresponding author), Benjamin A. Pinsky, Jeyarama S. Ananta, Su Zhao, Shylaja Arulkumar, Hao Wan, Malaya K. Sahoo, Janaki Abeynayake, Jesse J. Waggoner, Clay Hopes, Meijie Tang and Hongjie Dai. “Diagnosis of Zika virus infection on a nanotechnology platform” Nature Medicine, 23, 548, 2017.

2. Christelle Pomares, Bo Zhang (co-1st and Corresponding author), Shylaja Arulkumar, Geraldine Gonfrier, Pierre Marty, Su Zhao, Steven Cheng, Meijie Tang, Hongjie Dai and Jose Montoya. “Validation of IgG, IgM multiplex plasmonic gold platform in French clinical cohorts for the serodiagnosis and follow up of Toxoplasma gondii infection” Diagnostic Microbiology & Infectious Disease, 87, 213, 2017.

3. Xiaohua Chen, Odgerel Oidovsambuu, Ping Liu, Rosslyn Grosely, Menashe Elazar, Virginia D Winn, Benjamin Fram, Zhang Bo, Hongjie Dai, Bekhbold Dashtseren, Dahgwahdorj Yagaanbuyant, Zulkhuu Genden, Naranbaatar Dashdorj, Andreas Bungert, Naranjargal Dashdorj, Jeffrey S Glenn. “A novel quantitative microarray antibody capture (QMAC) assay identifies an extremely high HDV prevalence amongst HBV infected Mongolians” Hepatology, DOI: 10.1002/hep.28957, 2016.

4. Shoujun Zhu, Qinglai Yang, Alexander Antaris, Jingying Yue, Zhuoran Ma, Huasen Wang, Wei Huang, Hao Wan, Joy Wang, Shuo Diao, Bo Zhang, Xiaoyang Li, Yeteng Zhong, Kuai Yu, Guosong Hong, Jian Luo, Yongye Liang and Hongjie Dai. “Molecular imaging of biological systems with a clickable dye in the broad 800- to 1700-nm near-infrared window” Proceedings of the National Academy of Sciences, 114, 962, 2016.

5. Bin Liu, Yaling Li, Hao Wan, Lin Wang, Wei Xu, Shoujun Zhu, Yongye Liang, Bo Zhang, Jiatao Lou, Hongjie Dai and Kun Qian. “High performance, multiplexed lung cancer biomarker detection on a plasmonic gold chip” Advanced Functional Materials, 26, 7994, 2016.

6. Byumseok Koh, Xiaoyang Li, Bo Zhang, Bing Yuan, Yi Lin, Alexander L. Antaris, Hao Wan, Ming Gong, Jiang Yang, Xiaodong Zhang, Yongye Liang, and Dai. "Visible to Near-Infrared Fluorescence Enhanced Cellular Imaging on Plasmonic Gold Chips" Small, 12, 457, 2016.

7. Alexander L Antaris, Hao Chen, Kai Cheng, Yao Sun, Guosong Hong, Chunrong Qu, Shuo Diao, Zixin Deng, Xianming Hu, Bo Zhang, Xiaodong Zhang, Omar K Yaghi, Zita R Alamparambil, Xuechuan Hong, Zhen Cheng and Hongjie Dai. “A small-molecule dye for NIR-II imaging” Nature materials, 15, 235, 2015.

8. Shuo Diao, Jeffrey L Blackburn, Guosong Hong, Alexander L Antaris, Junlei Chang, Justin Z Wu, Bo Zhang, Kai Cheng, Calvin J Kuo and Hongjie Dai. “Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm” Angewandte Chemie, 127, 14971, 2015.

9. Valentina Manfe, Jan Fleckner, Peder Norby Lisby, Bo Zhang, Hongjie Dai and Pernille Keller. “Cytokine detection and simultaneous assessment of rheumatoid factor interference in human serum and synovial fluid using high-sensitivity protein arrays on plasmonic gold chips” BMC Biotechnology, 15, 73, 2015.

10. Changxin Chen, Justin Zachary Wu, Kai Tak Lam, Guosong Hong, Ming Gong, Bo Zhang, Yang Lu, Alexander L. Antaris, Shuo Diao, Jing Guo, and Hongjie Dai. "Graphene Nanoribbons Under Mechanical Strain" Advanced Materials, 27, 303-309, 2015.

11. Bo Zhang, Rajiv Kumar, Hongjie Dai and Brian Feldman. “A plasmonic Chip for Biomarker Discovery and Diagnosis of Type-1 Diabetes.Nature Medicine, 20, 948, 2014.

12. Bo Zhang, Jiang Yang, Yingping Zou, Ming Gong, Hui Chen, Guosong Hong, Alexander L. Antaris, Xiaoyang Li, Chien-Liang Liu, Changxin Chen and Hongjie Dai. “Plasmonic micro-beads for fluorescence enhanced, multiplexed protein detection with flow cytometry.Chemical Science, 5, 4070, 2014.

13. Guosong Hong, Shuo Diao, Junlei Chang, Alexander L. Antaris, Changxin Chen, Bo Zhang, Su Zhao, Dmitriy N. Atochin, Paul L. Huang, Katrin I. Andreasson, Calvin J. Kuo, and Hongjie Dai. Through-skull fluorescence imaging of the brain in a new near-infrared window. Nature Photonics, 8, 723, 2014.

14. Ming Gong, Wu Zhou, Mon-Che Tsai, Jigang Zhou, Mingyun Guan, Meng-Chang Lin, Bo Zhang, Yongfeng Hu, Di-Yan Wang, Jiang Yang, Stephen J. Pennycook, Bing-Joe Hwang and Hongjie Dai. “Nanoscale nickel oxide/nickel heterostructures for active hydrogen evolution electrocatalysis. Nature Communications, 5, 4695, 2014.

15. Guosong Hong, Yingping Zou, Alexander L. Antaris, Shuo Diao, Di Wu, Kai Cheng, Xiaodong Zhang, Changxin Chen, Bo Liu, Yuehui He, Justin Z. Wu, Jun Yuan, Bo Zhang, Zhimin Tao, Chihiro Fukunaga and Hongjie Dai. Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window. Nature Communications, 5, 4206, 2014.

16. Xiaobin Tang, Bo Zhang, Justin A. Jarrell, Jordan V. Price, Hongjie Dai, Paul J Utz and Sam Strober. “Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.Journal of Autoimmunity, 50, 87, 2014

.17. Ming Gong, Yanguang Li, Hongbo Zhang, Bo Zhang, Wu Zhou, Ju Feng, Hailiang Wang, Yongye Liang, Zhuangjun Fan, Jie Liu and Hongjie Dai. Ultrafast high-capacity NiZn battery with NiAlCo-layered double hydroxide. Energy and Environmental Science, 135 (23), 8452, 2014.

18. Zhimin Tao, Guosong Hong, Chihiro Shinji, Changxin Chen, Shuo Diao, Alexander L. Antaris, Bo Zhang, Yingping Zou and Hongjie Dai. Biological imaging using nanoparticles of small organic molecules with fluorescence at wavelengths longer than 1000 nm. Angewante Chemie, 125 (49), 13240, 2013.

19. Bo Zhang, Justin A. Jarrell, Jordan V. Price, Scott M. Tabakman, Yanguang Li, Ming, Gong, Guosong Hong, Ju Feng, Paul J. Utz and Hongjie Dai. “An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling.Plos ONE, 8, e71043, 2013.

20. Yanguang Li, Ming Gong, Yongye Liang, Ju Feng, Ji-Eun Kim, Hailiang Wang, Guosong Hong, Bo Zhang and Hongjie Dai. Advanced zinc-air batteries based on high-performance hybrid electrocatalysts. Nature Communications, 4, 1805, 2013.

21. Bo Zhang, Jordan Price, Guosong Hong, Scott M. Tabakman, Hailiang Wang, Justin A. Jarrell, Ju Feng, Paul J. Utz and Hongjie Dai. “Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence.Nano Research, 6, 113, 2013.

22. Ju Feng, Yongye Liang, Hailiang Wang, Yanguang Li, Bo Zhang, Jigang Zhou, Jian Wang, Tom Regier and Hongjie Dai. Engineering manganese oxide/nanocarbon hybrid materials for oxygen reduction electrocatalysis. Nano Research, 5 (10), 718, 2012.

23. Joshua T. Robinson, Guosong Hong, Yongye Liang, Bo Zhang, Omar K. Yaghi and Hongjie Dai. In vivo fluorescence imaging in the second near-infrared window with long circulating carbon nanotubes capable of ultrahigh tumor uptake. Journal of the American Chemical Society, 134 (25), 10664, 2012.

24. Guosong Hong, Justin Z. Wu, Joshua T. Robinson, Hailiang Wang, Bo Zhang and Hongjie Dai. Three-dimensional imaging of single nanotube molecule endocytosis on plasmonic substrates. Nature Communications, 3, 700, 2012.

25. Scott M. Tabakman, Lana Lau, Joshua T. Robinson, Jordan Price, Sarah P. Sherlock, Hailiang Wang, Bo Zhang, Zhuo Chen, Stephanie Tangsombatvisit, Justin A. Jarrell, Paul J. Utz and Hongjie Dai. Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range. Nature Communications, 2, 466, 2011.

26. Guosong Hong, Scott M. Tabakman, Kevin Welsher, Zhuo Chen, Joshua T. Robinson, Hailiang Wang, Bo Zhang and Hongjie Dai. Near-infrared-fluorescence-enhanced molecular imaging of live cells on gold substrates. Angewante Chemie, 50, 4644, 2011.

27. Guo Hong, Bo Zhang, Banghua Peng, Xiaojun Xian, Jin Zhang, WonMook Choi, Jae-Young Choi, Jong Min Kim and Zhongfan Liu. Direct growth of semiconducting single-walled carbon nanotube array. Journal of the American Chemical Society, 131, 14642, 2009.

28. Bo Zhang, Guo Hong, Banghua Peng, Jin Zhang, WonMook Choi, Jong Min Kim, Jae- Young Choi, and Zhongfan Liu. “Grow Single-Walled Carbon Nanotubes Cross-Bar in One Batch.J. Phys. Chem. C, 113, 5341, 2009. (Cover Art)